Nanoscale 3D Imaging

THE NEXT EVOLUTION IN SPATIAL BIOLOGY

Quantify drug localization and tissue response at the subcellular level in intact tissue. Validate therapeutics and de-risk your pipeline with robust data & precision imaging.

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What We Do

We help research teams characterize the complex interactions between drug candidates and biological tissue. By combining Nanoscale 3D Imaging with AI-based segmentation, we visualise and quantify subcellular treatment effects including changes in cell structure, biomarker distribution and tissue organization. Our goal is to provide the high-resolution, spatial data needed to validate efficacy and support data-driven decisions in drug development pipelines.

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Testimonials

"Q32 Bio has collaborated with Magnephy on several preclinical studies, and the experience has been outstanding.  Magnephy brought a wealth of expertise to the table, carefully listening to the scientific questions we were trying to ask and suggesting potential solutions. During study execution the work was excellent, the communication prompt and clear, with regular check-ins to make sure they fully understood our needs and offers to modify the approach as the data emerged.

In the end, the results far exceeded even our most optimistic expectations... "

Founders in front of the nanoscale 3D microscopy system used for Magnephy’s tissue imaging and analysis.

Our Technology

From Sample to Subcellular Insight: How does it work?

We provide an end-to-end workflow designed to transform complex tissue into actionable 3D data.

Advanced Sample Preparation

We utilize specialized tissue clearing and expansion protocols to achieve the highest possible image quality for deep 3D visualization.

3D Nanoimaging

Samples are imaged using advanced light microscopy, such as STED microscopy, to achieve unprecedented subcellular resolution in 3D.

AI-Based Quantification

We then apply proprietary AI algorithms to segment and quantify subcellular features in 3D. This converts raw imaging into actionable data for data-driven drug development decisions.

All analyses are performed at our state-of-the-art laboratory at SciLifeLab in Stockholm. Our process is compatible with all standard sample preparations. Simply send us your sample, and we handle the rest.

Publications

Deep learning–based segmentation and quantification of podocyte foot process morphology suggests differential patterns of foot process effacement across kidney pathologies

David Unnersjö-Jess, et al., – 2023

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